COSMEDOCS
    Harley Street Doctors • Since 2007

    Medically reviewed by Dr Hena Haq, Aesthetic Physician, Cosmedocs Harley StreetGMC 7223492Last reviewed

    Polynucleotide Therapy

    Next-generation DNA repair therapy that regenerates skin at a cellular level — for lasting quality improvement from within.

    Doctor-Led20–30 MinSince 2007From £350

    What Are Polynucleotides?

    Polynucleotides (PDRN) are purified DNA fragments derived from salmon or trout DNA. When injected, they stimulate cellular repair, boost collagen synthesis, and enhance skin regeneration at a fundamental level.

    Unlike hyaluronic acid treatments that primarily hydrate, polynucleotides work by activating your skin's own repair mechanisms. They promote fibroblast activity, improve blood flow, and reduce inflammation — addressing the root causes of skin ageing rather than just its symptoms.

    This makes polynucleotide therapy particularly effective for patients who want genuine skin regeneration — not just temporary hydration or volumisation. Results develop progressively and continue improving for months after treatment.

    Treatment Areas

    Under Eyes & Dark Circles

    Reduces hollowing, dark circles, and crepey skin around the delicate eye area.

    Face & Neck

    Improves overall skin quality, texture, and firmness for natural rejuvenation.

    Scalp & Hair

    Stimulates hair follicle regeneration and promotes natural hair growth.

    Hands & Décolletage

    Addresses thinning skin, age spots, and loss of elasticity in exposed areas.

    Am I Suitable?

    May Be Suitable

    • • Dark circles and under-eye hollowing
    • • Fine lines and skin laxity
    • • Dull, tired-looking skin
    • • Hair thinning or early hair loss
    • • Sun-damaged or ageing skin

    May Not Be Suitable

    • • Known fish allergy (salmon-derived PDRN)
    • • Active skin infections
    • • Pregnancy or breastfeeding
    • • Autoimmune conditions

    Before & After

    Polynucleotide lip rejuvenation before and after
    Polynucleotide under-eye treatment before and after
    Polynucleotide eyebrow area treatment before and after
    Polynucleotide scalp hair restoration before and after

    Individual results vary. Images show real patients treated at our Harley Street clinic.

    Why Cosmedocs?

    • Doctor-led — all treatments by GMC-registered doctors
    • Harley Street, London — established 2007
    • Over 1 million treatments performed
    • Advanced regenerative medicine expertise
    • Personalised treatment plans
    • Our aesthetics is invisible art

    Frequently Asked Questions

    At Cosmedocs Harley Street, polynucleotide treatments start from £350 per session. A course of 3 sessions is recommended for optimal results. Cost depends on the treatment area and your specific goals.

    Results typically last 6–9 months and continue improving over time. Regular maintenance sessions can help sustain your natural transformation.

    Yes, polynucleotide treatment is very safe when performed by experienced practitioners. It uses biocompatible DNA fragments naturally found in the body, minimising the risk of allergic reactions.

    Polynucleotides can treat the under-eye area, face, neck, décolletage, hands, and scalp. They're particularly effective for dark circles, fine lines, skin texture improvement, and hair loss.

    While improvements can be seen after one session, we recommend 3 sessions spaced 3 weeks apart for optimal and lasting results.

    Yes, polynucleotide therapy is highly effective for hair restoration. It stimulates follicle regeneration, improves scalp health, and promotes natural hair growth.

    While both improve skin quality, polynucleotides work at a cellular DNA level to repair and regenerate tissue, whereas Profhilo uses hyaluronic acid for hydration and bio-remodelling. They can be combined for comprehensive results.

    Considering Polynucleotides?

    A consultation will help determine whether polynucleotide therapy is right for you.

    At a Glance

    Duration

    20–30 minutes

    Results last

    6–12 months

    Recovery

    Minimal downtime

    Product

    PDRN / Polynucleotides

    Treatment Pricing

    Per sessionFrom £350

    Personalised plan after consultation

    L

    Laura K.

    "The polynucleotide treatment has genuinely transformed my skin texture. It looks healthier and more radiant than it has in years."

    More real experiences
    Book Consultation

    Daily Skincare

    Keep your results lasting longer

    Two doctor-formulated essentials for between appointments.

    Revitalise C20 Vitamin C Serum
    Morning

    Revitalise C20

    Vitamin C Serum · £85

    Stimulate RE Retinol+ Cream
    Evening

    Stimulate RE

    Retinol+ Night Cream · £65

    Shop the routine